HCID 67133050, compound → HCID 67133348, compound

Participants

Reaction Steps

A solution of 6.15 g (27.4 mmol) of 2-(3-hex-1-ynyl-phenyl)-1H-imidazole in 140 ml of MeOH was treated with 1.46 g (1.4 mmol) of Pd—C (10%) and hydrogenated with H2 (1 bar) at RT for 1 hour. After removal the catalyst by filtration, the solvent was evaporated. The residue was purified by flash column chromatography (CH2Cl2/MeOH 1:0 to 98:2) to give 5.92 g (95%) of the title compound as light brown solid. MS: 229.2 (MH+).

Provenance & Evidence