Glyoxal → HCID 67133190, compound

Participants

Reaction Conditions

Reaction Steps

8.17 ml=6.62 g (113.6 mmol) of cyclopropylamine and 8.90 g (113.6 mmol) of ammonium acetate were added to a solution of 6.80 g (37.9 mmol) of 3-(trifluoromethyl)benzaldehyde in 60 ml of MeOH and the reaction mixture was cooled down to 0° C. While stirring, 9.59 ml=16.49 g (113.6 mmol) of glyoxal solution (40% in water) was added and then the reaction was warmed up to 50° C. After cooling down to RT, the solvents were evaporated and the residue dissolved in water and Et2O. The reaction mixture was extracted three times with Et2O; the organic phases were washed with water, dried over magnesium sulfate, filtered and evaporated. The residue was purified by flash column chromatography (CH2Cl2) to give 1.96 g (21%) of the title compound as light red oil. MS: 253.1 (MH+).

Provenance & Evidence