Ethyl bromoacetate → Glycine, N-cyclopropyl-, ethyl ester

HRID 545335Notes

Reaction equation

HRID 545335 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[CH2:5]([O:7][C:8](=[O:11])[CH2:9]Br)[CH3:6]>CCO>[CH2:5]([O:7][C:8](=[O:11])[CH2:9][NH:4][CH:1]1[CH2:3][CH2:2]1)[CH3:6]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 69828Cyclopropylamine

Product 1

HCID 22476174Glycine, N-cyclopropyl-, ethyl ester

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 10 g (0.18 mol) of cyclopropylamine in 50 ml of EtOH was added 7 g (0.04 mol) of ethylbromoacetate and the reaction stirred for 1 h. The reaction was then evaporated to dryness, redissolved in CH2Cl2 washed with water, dried over sodium sulfate and concentrated to afford 6 g (quant.) of the title compound as a colorless oil. MS: 144.1 (MH+).

Workup

  1. customThe reaction was then evaporated to dryness
  2. dissolutionredissolved in CH2Cl2
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-3b40fb8c207c44a1bf891db0416622ed
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

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