反应详情

温度

110 °C

To 0.15 g (0.4 mmol) of 2-[cyclopropyl-(4-trifluoromethoxy-benzoyl)-amino]-3-oxo-butyric acid ethyl ester in 5 ml of MeOH was added 0.2 g (1.5 mmol) of ammonium trifluoroacetate. The MeOH was evaporated and the residue heated to 110° C. for 4 h. The cooled residue was partitioned between saturated sodium hydrogen carbonate solution and CH2Cl2. The organic phase was dried with sodium sulfate and concentrated. Purification by flash column chromatography [n-heptane/EtOAc 3:7 to 1:1] afforded 0.1 g (73%) of the title compound as a colorless solid. MS: 355.2 (MH+).

1. customThe MeOH was evaporated
2. customThe cooled residue was partitioned between saturated sodium hydrogen carbonate solution and CH2Cl2
3. dry with materialThe organic phase was dried with sodium sulfate
4. concentrationconcentrated
5. customPurification by flash column chromatography [n-heptane/EtOAc 3:7 to 1:1]