Sodium Hydroxide → HCID 67133057, compound

HRID 545342Notes

Reaction equation

HRID 545342 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH:28]2[CH2:30][CH2:29]2)[C:8]([C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=2)=[N:9][C:10]=1[C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)=[O:5])C.[OH-].[Na+:32]>CCO>[Na+:32].[CH:28]1([N:7]2[C:6]([C:4]([O-:5])=[O:3])=[C:10]([C:11]3[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=3)[N:9]=[C:8]2[C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:26])([F:27])[F:25])=[CH:19][CH:18]=2)[CH2:30][CH2:29]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 671331703-Cyclopropyl-5-pyridin-3-yl-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid ethyl ester

Product 1

HCID 67133057HCID 67133057, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 0.9 g (2 mmol) 3-cyclopropyl-5-pyridin-3-yl-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid ethyl ester in 5 ml of EtOH was added 0.4 ml of 6 M sodium hydroxide solution (2 mmol) and the mixture heated to reflux for 6 h. The solvent was then evaporated, affording 1.0 g (quant.) of the title compound as a white solid. MS: 390.1 (MH+).

Workup

  1. temperaturethe mixture heated
  2. temperatureto reflux for 6 h
  3. customThe solvent was then evaporated

Sources & evidence

ORD record
ord-dfd3d56ac12c41eabb9493bd99049aa9
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

Loading…