HRID545343

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID277238

6-(Benzyloxy)pyridine-3-carboxylic acid

C13H11NO3

结构：CCOC(=O)CN(C(=O)c1ccc(OC(F)(F)F)cc1)C1CC1

HCID67133328

未命名化合物

2 次

PRODUCTS

生成物

结构：CCOC(=O)C(C(=O)c1ccc(OCc2ccccc2)nc1)N(C(=O)c1ccc(OC(F)(F)F)cc1)C1CC1

HCID67133030

未命名化合物

PROCEDURE

实验过程

The title compound, a colorless oil (1.5 g, 62%), was prepared in analogy to intermediate 8A by reaction of [cyclopropyl-(4-trifluoromethoxy-benzoyl)-amino]-acetic acid ethyl ester (intermediate 7B) with 6-(benzyloxy)nicotinic acid. MS: 543.2 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-626a495b7be34e399dcae0feba0ca73f
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07935707B2
来源说明: uspto-grants-2011_05

反应 SMILES

[CH2:1]([O:3][C:4](=[O:23])[CH2:5][N:6]([CH:20]1[CH2:22][CH2:21]1)[C:7](=[O:19])[C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][CH:9]=1)[CH3:2].[CH2:24]([O:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][N:33]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:1]([O:3][C:4](=[O:23])[CH:5]([N:6]([CH:20]1[CH2:22][CH2:21]1)[C:7](=[O:19])[C:8]1[CH:9]=[CH:10][C:11]([O:14][C:15]([F:16])([F:17])[F:18])=[CH:12][CH:13]=1)[C:36]([C:35]1[CH:34]=[N:33][C:32]([O:31][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:40][CH:39]=1)=[O:37])[CH3:2]