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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 545347Generated: October 28, 2026

Ammonium trifluoroacetate → 3-Cyclopropyl-5-(2-methylsulfanyl-pyrimidin-5-yl)-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid ethyl ester

https://huagongshe.com/reaction/545347

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmonium trifluoroacetateHCID 2724268—
Reactant2-[Cyclopropyl-(4-trifluoromethoxy-benzoyl)-amino]-3-(2-methylsulfanyl-pyrimidin-5-yl)-3-oxo-propionic acid ethyl esterHCID 67133087—
Product3-Cyclopropyl-5-(2-methylsulfanyl-pyrimidin-5-yl)-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid ethyl esterHCID 67133092—

Reaction Steps

The title compound was prepared from 2-[cyclopropyl-(4-trifluoromethoxy-benzoyl)-amino]-3-(2-methylsulfanyl-pyrimidin-5-yl)-3-oxo-propionic acid ethyl ester in direct analogy to intermediate 8B, by reaction with ammonium trifluoroacetate. MS: 465.1 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07935707B2
Source datasetuspto-grants-2011_05
ORD IDord-d739b9756aa3406a92e24a25b6c31733
Source noteuspto-grants-2011_05