1-Benzyl-1H-pyrazole-4-carboxylic acid → 3-(1-Benzyl-1H-pyrazol-4-yl)-2-[cyclopropyl-(4-trifluoromethoxy-benzoyl)-amino]-3-oxo-propionic acid ethyl ester

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Reaction Steps

The title compound, a colorless oil (0.9 g, 41%), was prepared in analogy to intermediate 8A by reaction of [cyclopropyl-(4-trifluoromethoxy-benzoyl)-amino]-acetic acid ethyl ester (intermediate 7B) with 1-benzyl-1H-pyrazole-4-carboxylic acid (Kalla R. V.; Elzein E.; Perry T.; Li X.; Palle V.; Varkhedkar V.; Gimbel A.; Maa T.; Zeng D.; Zablocki J. Journal of Medicinal Chemistry (2006), 49(12), 3682-92).MS: 516.1 (MH+).

Provenance & Evidence