Lithium Hydroxide → HCID 67133045, compound

Participants

Reaction Steps

A solution of 0.076 g (1.87 mmol) of 3-cyclopropyl-5-furan-2-yl-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid ethyl ester and 0.013 g (5.42 mmol) of LiOH in 4 ml of THF, 2 ml of MeOH and 2 ml of H2O was stirred at 80° C. for 4.5 hours. The reaction mixture was then cooled to RT, diluted with EtOAc and washed with 10% KHSO4 solution and brine. The aqueous phases were extracted twice with EtOAc. The organic layers were dried over magnesium sulfate, filtered and concentrated in vacuo to give 69 mg (96%) of the title compound as white powder. MS: 377.1 (MH+).

Provenance & Evidence