Dimethylformamide → HCID 57541146, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.275 g (0.50 mmol) of [2-(3-hexyl-phenyl)-5-iodo-3-methyl-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 2) in 10 ml of DMF was treated with 0.118 g (1.0 mmol) of zinc cyanide and 0.058 g (0.05 mmol) of tetrakis-(triphenylphosphine)-palladium. This reaction mixture was heated up to 150° C., stirred for 8 hours at this temperature and subsequently cooled down to RT. Then, it was poured into crashed ice and extracted three times with CH2Cl2; the organic phases were washed with water, dried over magnesium sulfate, filtered and evaporated. The residue was purified by flash column chromatography (CH2Cl2/MeOH 1:0 to 9:1) to give 0.18 g (81%) of the title compound as light yellow oil. MS: 448.2 (MH+).

Provenance & Evidence