(Pyrimidin-5-yl)boronic acid → HCID 25113643, compound

HRID 545383Notes

Reaction equation

HRID 545383 reaction equation
I[C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]([F:17])([F:16])[F:15])[CH:8]=2)[N:4]([CH3:18])[C:3]=1[C:19]([N:21]1[CH2:26][CH2:25][CH:24]([N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[CH2:23][CH2:22]1)=[O:20].[N:32]1[CH:37]=[C:36](B(O)O)[CH:35]=[N:34][CH:33]=1>>[CH3:18][N:4]1[C:3]([C:19]([N:21]2[CH2:26][CH2:25][CH:24]([N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)[CH2:23][CH2:22]2)=[O:20])=[C:2]([C:36]2[CH:37]=[N:32][CH:33]=[N:34][CH:35]=2)[N:6]=[C:5]1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]([F:17])([F:16])[F:15])[CH:8]=1

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 25152481HCID 25152481, compound

Product 1

HCID 25113643HCID 25113643, compound

Procedure

In analogy to the procedure described for example 7, [5-iodo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 19) was reacted with pyrimidine-5-yl-boronic acid to give the title compound as colorless foam. MS: 501.1 (MH+).

Sources & evidence

ORD record
ord-17bc75e278d0457fb03da7cc96345c40
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

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