HCID 25152483, compound → HCID 57541134, compound

HRID 545400Notes

Reaction equation

HRID 545400 reaction equation
[C:1]([C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:5]([CH3:18])[C:4]=1[C:19]([N:21]1[CH2:26][CH2:25][CH:24]([N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[CH2:23][CH2:22]1)=[O:20])#[CH:2]>[Pt]=O>[CH2:1]([C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=2)[N:5]([CH3:18])[C:4]=1[C:19]([N:21]1[CH2:22][CH2:23][CH:24]([N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[CH2:25][CH2:26]1)=[O:20])[CH3:2]

Participants

3

Reactant 1

HCID 25152483HCID 25152483, compound

Product 1

HCID 57541134HCID 57541134, compound

Reagents, catalysts & solvents 1

HCID 82844Platinum oxide (PtO)Catalyst

Procedure

In analogy to the procedure described for example 14, [5-ethynyl-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 41) was hydrogenated using platinum oxide as catalyst to give the title compound as yellow foam. MS: 435.3 (MH+).

Sources & evidence

ORD record
ord-1114b15cf49a49fda4df0881565260a1
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

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