HuagongsheHuagongshe Chemistry Print Report · For research reference only
((R)-1-Piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride → [4-((R)-2-Hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-[5-iodo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ((R)-1-Piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride | HCID 67133026 | — |
| Reactant | 5-iodo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid | HCID 67133255 | — |
| Product | [4-((R)-2-Hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-[5-iodo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-methanone | HCID 57541087 | — |
Reaction Steps
In analogy to the procedure described for example 2, 5-iodo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid (example 19) and ((R)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride (intermediate 2) gave the title compound as light red amorphous solid. MS: 579.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935707B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-1d5f75ec605e4a12b0595b41f53799bf |
| Source note | uspto-grants-2011_05 |