((R)-1-Piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride → [4-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-[5-iodo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-methanone

Participants

Reaction Steps

In analogy to the procedure described for example 2, 5-iodo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid (example 19) and ((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride [prepared as described for ((R)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride (intermediate 2), but starting from (S)-(−)-pyrrolidin-2-yl-methanol] gave the title compound as brown amorphous solid. MS: 579.1 (MH+).

Provenance & Evidence