(Pyrimidin-5-yl)boronic acid → [4-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-[3-methyl-5-pyrimidin-5-yl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-methanone

Participants

Reaction Steps

In analogy to the procedure described for example 7, [4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-[5-iodo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-yl]-methanone (example 53) was reacted with pyrimidine-5-yl-boronic acid to give the title compound light brown oil. MS: 531.1 (MH+).

Provenance & Evidence