(Pyridin-4-yl)boronic acid → HCID 57541099, compound

HRID 545414Notes

Reaction equation

HRID 545414 reaction equation
[CH:1]1([CH2:4][N:5]2[C:9]([C:10]([N:12]3[CH2:17][CH2:16][CH:15]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[CH2:14][CH2:13]3)=[O:11])=[C:8](I)[N:7]=[C:6]2[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=2)[CH2:3][CH2:2]1.[N:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1>>[CH:1]1([CH2:4][N:5]2[C:9]([C:10]([N:12]3[CH2:17][CH2:16][CH:15]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[CH2:14][CH2:13]3)=[O:11])=[C:8]([C:37]3[CH:38]=[CH:39][N:34]=[CH:35][CH:36]=3)[N:7]=[C:6]2[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 57541118HCID 57541118, compound

Product 1

HCID 57541099HCID 57541099, compound

Procedure

In analogy to the procedure described for example 7, [3-cyclopropylmethyl-5-iodo-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 56) was reacted with pyridin-4-yl-boronic acid to give the title compound light yellow amorphous solid. MS: 524.5 (MH+).

Sources & evidence

ORD record
ord-6bd79d9608644fa6a33fabfdc3977a7a
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

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