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[1,4'-Bipiperidin]-3-ol → (Rac)-(3-hydroxy-[1,4']bipiperidinyl-1'-yl)-[5-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3h-imidazol-4-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | [1,4'-Bipiperidin]-3-ol | HCID 21091574 | — |
| 反応物 | 5-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carboxylic acid | HCID 67133231 | — |
| 生成物 | (Rac)-(3-hydroxy-[1,4']bipiperidinyl-1'-yl)-[5-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3h-imidazol-4-yl]-methanone | HCID 57541103 | — |
反応手順
In analogy to the procedure described for example 2, 5-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carboxylic acid (example 36) was coupled with (rac)-[1,4′]bipiperidinyl-3-ol to give the title compound as off-white solid. MS: 563.2 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07935707B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-54834fbcda474a9380af99baa2752d52 |
| 出典メモ | uspto-grants-2011_05 |