(Pyrimidin-5-yl)boronic acid → HCID 25152891, compound

HRID 545420Notes

Reaction equation

HRID 545420 reaction equation
[CH:1]1([N:4]2[C:8]([C:9]([N:11]3[CH2:16][CH2:15][CH:14]([N:17]4[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH2:13][CH2:12]3)=[O:10])=[C:7](I)[N:6]=[C:5]2[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)[CH2:3][CH2:2]1.[N:33]1[CH:38]=[C:37](B(O)O)[CH:36]=[N:35][CH:34]=1>>[CH:1]1([N:4]2[C:8]([C:9]([N:11]3[CH2:16][CH2:15][CH:14]([N:17]4[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH2:13][CH2:12]3)=[O:10])=[C:7]([C:37]3[CH:38]=[N:33][CH:34]=[N:35][CH:36]=3)[N:6]=[C:5]2[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 57541116HCID 57541116, compound

Product 1

HCID 25152891HCID 25152891, compound

Procedure

In analogy to the procedure described for example 7, [3-cyclopropyl-5-iodo-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 63) was reacted with pyrimidine-5-yl-boronic acid to give the title compound as yellow amorphous solid. MS: 511.2 (MH+).

Sources & evidence

ORD record
ord-da91cd9dcabe492db3a8af54862f08a7
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

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