(Pyridin-4-yl)boronic acid → HCID 57541138, compound

HRID 545423Notes

Reaction equation

HRID 545423 reaction equation
[CH2:1]([N:3]1[C:7]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])=[C:6](I)[N:5]=[C:4]1[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=1)[CH3:2].[N:32]1[CH:37]=[CH:36][C:35](B(O)O)=[CH:34][CH:33]=1>>[CH2:1]([N:3]1[C:7]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])=[C:6]([C:35]2[CH:36]=[CH:37][N:32]=[CH:33][CH:34]=2)[N:5]=[C:4]1[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 57541131HCID 57541131, compound

Product 1

HCID 57541138HCID 57541138, compound

Procedure

In analogy to the procedure described for example 7, [3-ethyl-5-iodo-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 69) was reacted with pyridine-4-yl-boronic acid to give the title compound as light yellow solid. MS: 498.1 (MH+).

Sources & evidence

ORD record
ord-74b074ca6c00495586389f5d5fd55e1f
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

Loading…