(Pyrimidin-5-yl)boronic acid → HCID 57541120, compound

HRID 545424Notes

Reaction equation

HRID 545424 reaction equation
[CH2:1]([N:3]1[C:7]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])=[C:6](I)[N:5]=[C:4]1[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=1)[CH3:2].[N:32]1[CH:37]=[C:36](B(O)O)[CH:35]=[N:34][CH:33]=1>>[CH2:1]([N:3]1[C:7]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])=[C:6]([C:36]2[CH:37]=[N:32][CH:33]=[N:34][CH:35]=2)[N:5]=[C:4]1[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 57541131HCID 57541131, compound

Product 1

HCID 57541120HCID 57541120, compound

Procedure

In analogy to the procedure described for example 7, [3-ethyl-5-iodo-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 69) was reacted with pyrimidine-5-yl-boronic acid to give the title compound as light yellow solid. MS: 499.2 (MH+).

Sources & evidence

ORD record
ord-35ba43db01734fba96c8c1e16cee155c
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

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