Hydrochloric Acid → [5-Bromo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone

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Reaction Steps

A solution of 0.15 g (0.24 mmol) of benzoic acid (S)-1-{1-[5-bromo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-carbonyl]-piperidin-4-yl}-pyrrolidin-2-ylmethyl ester [prepared in analogy to the procedure described for example 2 from 5-bromo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid (example 72) and benzoic acid (S)-1-piperidin-4-yl-pyrrolidin-2-ylmethyl ester (intermediate 6C)] in 10 ml of THF/MeOH 1:1 was treated with 0.59 ml (0.59 mmol) of a LiOH solution (1.0 molar in H2O) and the mixture was stirred for 20 hours at RT. It was then poured into crashed ice, acidified with HCl (1.0 N) and extracted twice with EtOAc; the organic phases were washed with water, dried over magnesium sulfate, filtered and evaporated. The residue was purified by flash column chromatography (CH2Cl2/MeOH 98:2 to 4:1) to give 0.128 g (quant.) of the title compound as colorless amorphous solid. MS: 531.0 (MH+, 1Br).

Provenance & Evidence