4-(1-Pyrrolidinyl)piperidine → [3-Cyclopropyl-5-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Participants

Reaction Steps

In analogy to the procedure described for example 2, the title compound has been obtained by coupling of 3-cyclopropyl-5-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid (prepared in analogy to the sequence described for the preparation of intermediate 7, but using 3-trifluoromethoxy-benzoyl chloride instead of 4-trifluoromethoxy-benzoyl chloride in step 7B) with 4-pyrrolidin-1-yl-piperidine to give the title compound as colorless amorphous solid. MS: 463.3 (MH+).

Provenance & Evidence