4-(1-Pyrrolidinyl)piperidine → [3-Cyclopropyl-5-pyridin-3-yl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

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Reaction Steps

In analogy to the procedure described for example 2, the title compound has been obtained by coupling of 3-cyclopropyl-5-pyridin-3-yl-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid sodium salt (prepared in analogy to the sequence described for the preparation of intermediate 8, but using [cyclopropyl-(3-trifluoromethoxy-benzoyl)-amino]-acetic acid ethyl ester instead of [cyclopropyl-(4-trifluoromethoxy-benzoyl)-amino]-acetic acid ethyl ester in step 8A) with 4-pyrrolidin-1-yl-piperidine to give the title compound as a colorless amorphous solid. MS: 526.4 (MH+).

Provenance & Evidence