4-(1-Pyrrolidinyl)piperidine → HCID 178519280, compound

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Reaction Steps

In analogy to the procedure described for example 2, the title compound has been obtained by coupling of 3-cyclopropyl-5-(6-hydroxy-pyridin-3-yl)-2-(3-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid (prepared in analogy to the sequence described for the preparation of intermediate 9, using [cyclopropyl-(3-trifluoromethoxy-benzoyl)-amino]-acetic acid ethyl ester instead of [cyclopropyl-(4-trifluoromethoxy-benzoyl)-amino]-acetic acid ethyl ester in step 9A) with 4-pyrrolidin-1-yl-piperidine to give the title compound as a colorless amorphous solid. MS: 542.4 (MH+).

Provenance & Evidence