(Pyrimidin-5-yl)boronic acid → HCID 57541129, compound

HRID 545441Notes

Reaction equation

HRID 545441 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([CH3:14])[C:12]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:19][CH2:18]3)=[O:16])=[C:11](I)[N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[N:29]1[CH:34]=[C:33](B(O)O)[CH:32]=[N:31][CH:30]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([CH3:14])[C:12]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:19][CH2:18]3)=[O:16])=[C:11]([C:33]3[CH:34]=[N:29][CH:30]=[N:31][CH:32]=3)[N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 57541074HCID 57541074, compound

Product 1

HCID 57541129HCID 57541129, compound

Procedure

In analogy to the procedure described for example 7, [2-(3,4-dichloro-phenyl)-5-iodo-3-methyl-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 105) was reacted with pyrimidine-5-yl-boronic acid to give the title compound as colorless amorphous solid. MS: 485.3 (MH+, 2Cl).

Sources & evidence

ORD record
ord-568b96acd9de4f64af45e989afbdb059
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

Loading…