2-Methoxypyrimidine-5-boronic acid → [5-(2-Methoxy-pyrimidin-5-yl)-3-methyl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	2-Methoxypyrimidine-5-boronic acid	HCID 2736778	—
Reactant	[5-iodo-3-methyl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone	HCID 57541088	—
Product	[5-(2-Methoxy-pyrimidin-5-yl)-3-methyl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone	HCID 57541105	—

Reaction Steps

In analogy to the procedure described for example 7, [5-iodo-3-methyl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 104) was reacted with 2-methoxy-pyrimidin-5-yl-boronic acid to give the title compound as light yellow solid. MS: 515.3 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07935707B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-bd2547f728df49c583bdd85dd413b6d3
Source note	uspto-grants-2011_05