HCID 57443974, compound → HCID 131728275, compound

HRID 545460Notes

Reaction equation

HRID 545460 reaction equation
COC(C1SC2C=C(CO)C=CC=2C=1)=O.[ClH:16].[CH2:17]([O:19][C:20]([C:22]1[S:26][C:25]2[CH:27]=[C:28]([CH2:31][NH2:32])[CH:29]=[CH:30][C:24]=2[CH:23]=1)=[O:21])C>>[ClH:16].[CH3:17][O:19][C:20]([C:22]1[S:26][C:25]2[CH:27]=[C:28]([CH2:31][NH2:32])[CH:29]=[CH:30][C:24]=2[CH:23]=1)=[O:21]

Participants

3

Reactant 2

HCID 57443974HCID 57443974, compoundHCID 131728274HCID 131728274, compound

Product 1

HCID 131728275HCID 131728275, compound

Procedure

The title compound was prepared from 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid methyl ester in procedures similar to those described for the preparation of 6-aminomethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester, hydrochloride salt. 1H NMR (DMSO-d6, 200 MHz) δ 8.70 (brs, 2H), 8.24-8.12 (m, 2H), 8.05 (d, J=8.4 Hz, 1H), 7.63 (dd, J=8.0, 1.0 Hz, 1H), 4.20-4.14 (m, 2H), 3.88 (s, 3H). MS (EI): cal'd 222.0 (MH+), exp 222.1 (MH+).

Sources & evidence

ORD record
ord-25843524d934488d9edcd7a9b058f548
Source dataset
uspto-grants-2011_05
Patent number
US07935724B2

Reaction notes

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