Formaldehyde → N,N-Dimethylaniline

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Reaction Steps

Alternatively the reduction can be accomplished with sodium cyanoborohydride in an inert solvent such as acetonitrile, dimethylformamide, or tetrahydrofuran. An alkyl aldehyde such as formaldehyde can be used in excess to obtain a dimethyl aniline of formula (24) (R5 and R6 each represent methyl). The reaction is accomplished at room temperture to the reflux temperature of the solvent for about 4 to 48 hours. The product can be isolated by common extractive techniques and purified by silica gel chromatography.

Provenance & Evidence