3-Chloro-4-hydrazinobenzonitrile → HCID 57431653, compound

HRID 545521Notes

Reaction equation

HRID 545521 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[NH:10]N.O=[C:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20](=[O:24])[CH:21]([CH3:23])[CH3:22])[CH2:15][CH2:14]1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[C:4]2[C:3]=1[NH:10][C:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20](=[O:24])[CH:21]([CH3:22])[CH3:23])[CH2:15][C:14]2=1

Participants

3

Reactant 2

HCID 27969643-Chloro-4-hydrazinobenzonitrileHCID 215339942-Methyl-N-(4-oxocyclohexyl)propanamide

Product 1

HCID 57431653HCID 57431653, compoundYield 50%

Procedure

Prepare the title compound by essentially following the procedure as described in Preparation 4 (Method 2) with 2-chloro-4-cyanophenylhydrazine (Preparation 13) and N-(4-oxo-cyclohexyl)-isobutyramide, to obtain the title compound as a pink powder in 50% yield. MS (ES): m/z 316 (M+H), 314 (M−H); HPLC (Method A): Rt=1.96, (90%).

Sources & evidence

ORD record
ord-34ea8244276e4e96a2aa3b4939bac136
Source dataset
uspto-grants-2011_05
Patent number
US07935722B2

Reaction notes

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