3-Fluorobenzyl bromide → HCID 59161232, compound

HRID 545525Notes

Reaction equation

HRID 545525 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:21]#[N:22])[CH:5]=[C:6]2[C:14]=1[NH:13][C:12]1[CH2:11][CH2:10][CH:9]([NH:15][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])[CH2:8][C:7]2=1.[F:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH2:27]Br>>[Cl:1][C:2]1[CH:3]=[C:4]([C:21]#[N:22])[CH:5]=[C:6]2[C:14]=1[N:13]([CH2:27][C:26]1[CH:29]=[CH:30][CH:31]=[C:24]([F:23])[CH:25]=1)[C:12]1[CH2:11][CH2:10][CH:9]([NH:15][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])[CH2:8][C:7]2=1

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 57431653HCID 57431653, compound

Product 1

HCID 59161232HCID 59161232, compoundYield 10%

Procedure

Prepare the title compound by essentially following the procedure as described in Example 96 with N-(8-chloro-6-cyano-2,3,4,9-tetrahydro-1H-carbazol-3-yl)-isobutyramide (Preparation 18) and 3-fluorobenzyl bromide, to obtain the title compound as a white solid in 10% yield. MS (ES): 424 (M+1), 422 (M−1); HPLC (Method A): Rt=3.18 (92%).

Sources & evidence

ORD record
ord-f711da0c3ab641cbac7512a5e9c9ad73
Source dataset
uspto-grants-2011_05
Patent number
US07935722B2

Reaction notes

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