HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-(1-benzylpiperidin-4-yl)-2-propenenitrile → 3-(1-Benzylpiperidin-4-yl)propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-(1-benzylpiperidin-4-yl)-2-propenenitrile | HCID 19959219 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(1-Benzylpiperidin-4-yl)propanenitrile | HCID 19959256 | 48.7% |
Reaction Steps
A mixture of (E)-3-(1-benzylpiperidin-4-yl)-2-propenenitrile (5.5 g) and platinum(IV) oxide (0.5 g) in methanol (70 ml) was hydrogenated at atmospheric pressure for 8 hours. After platinum(IV) oxide was removed by filtration, the filtrate was evaporated in vacuo to give 3-(1-benzylpiperidin-4-yl)propanenitrile (2.7 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05622976 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-fbff4cd895f240f5b72f30be0cb0df21 |
| Source note | uspto-grants-1997_04 |