Dimethylformamide → HCID 67197922, compound

Participants

Reaction Steps

Combine 3-bromo-2-butanone (0.224 g, 1.48 mmol) and (R)-N-(9-(3-fluorobenzyl)-6-thiocarbamoyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl)isobutyramide (Preparation 22) (0.209 g, 0.493 mmol) and heat in DMF at 80° C. under nitrogen for 2 h. Upon cooling, dilute the mixture with water and collect the precipitate by filtration. Recrystallize from absolute EtOH to give yellow crystals: MS (ES): m/z 476 (M+1); HPLC: Rt=3.87 min (100%).

Provenance & Evidence