Dimethylcarbamoyl Chloride → HCID 59161235, compound

Participants

Reaction Steps

Prepare the title compound by essentially following the procedures as described in Example 162, using 6-amino-9-(3-fluoro-benzyl)-6,7,8,9-tetrahydro-5H-carbazole-3-carbonitrile hydrochloride (Preparation 54) and dimethylcarbamyl chloride. Purify by silica gel chromatography (30-70% (4% (2M NH3/MeOH)/CH2Cl2)/hexanes) to give the title compound in 69% yield as a white solid. MS (ES): m/z 391 (M+1), 389 (M−1); HPLC (Method B): Rt=4.11 min (99%).

Provenance & Evidence