4-Nitrophenyl chloroformate → HCID 57431674, compound

Participants

Reaction Steps

Prepare the title compound by essentially following the procedures as described in Example 162, using 6-amino-9-(3-fluoro-benzyl)-6,7,8,9-tetrahydro-5H-carbazole-3-carbonitrile hydrochloride (Preparation 51) and 4-nitrophenyl chloroformate. Purify by silica gel chromatography (50% (4% (2M NH3/MeOH)/CH2Cl2)/hexanes) to give the title compound in 33% yield as a white solid. MS (ES): m/z 346 (M-p-nitrophenolate); HPLC (Method B): Rt=2.23 min (86%).

Provenance & Evidence