Lithium Hydroxide → HCID 86638397, compound

Participants

Reaction Conditions

Reaction Steps

Add (R)-9-(3-fluorobenzyl)-6-isobutyrylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxylic acid methyl ester (2.54 g, 6.01 mmol) to a solution of excess LiOH in methanol/water/TBF (33:33:33) and stir for 24 h at 70° C. Concentrate in vacuo, partition between water and EtOAc/Et2O. Make the aqueous layer acidic with aqueous HCl and extract with EtOAc. Wash with brine, filter the solids from the EtOAc layer and slurry in hot EtOAc. Collect by filtration and dry to give 2.35 g (96%) of a white solid. MS (ES): m/z 409 (M+1), HPLC: Rt=1.93 (100%).

Provenance & Evidence