O-Methylhydroxylamine → HCID 72234593, compound

Participants

Reaction Steps

Combine cyclopropanecarboxylic acid[9-(3-fluoro-benzyl)-6-formyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-amide (Preparation 70) (0.32 g, 0.82 mmol), methoxylamine (0.21 g, 2.4 mmol), and sodium hydroxide (0.049 g, 1.3 mmol) in EtOH (15 mL). Add enough water to dissolve the sodium hydroxide and stir for 18 h. Dilute with water and extract with EtOAc. Dry EtOAc extracts over Na2SO4 and filter twice through a pad of silica to give 0.21 g (61%) of an off-white solid. MS (ES): m/z 420 (M+1).

Provenance & Evidence