Potassium Carbonate → HCID 16730183, compound

Participants

Reaction Steps

Methyl[3,5-bis(trifluoromethyl)benzyl][2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzyl]carbamate (100 mg, 0.171 mmol), methyl 2-chloro-2′-fluoro-5′-iodo-4′-methoxybiphenyl-4-carboxylate (71.9 mg, 0.171 mmol), 1,1′-bis(diphenylphosphino) ferrocene-palladium dichloride dichloromethane adduct (13.95 mg, 0.017 mmol), potassium carbonate (0.256 ml, 0.513 mmol) and 1,4-dioxane (1 ml) were sealed and subjected to microwave irradiation for 30 min at 140° C. An aliquot indicated formation of the desired product. The crude reaction mixture was dried over Na2SO4. The resulting dark mixture was purified by preparative TLC (silica gel) developed by EtOAc/hexanes (20%, v/v) mixture to give a green glass as the title compound. LCMS calc.=751.12; found=752.36 (M+1)+.

Provenance & Evidence