HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 54563Generated: October 27, 2026
Ethyl Acetate → 3-[{2-(1-Tert-butoxycarbonylpiperidin-4-yl)ethyl}carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole
https://huagongshe.com/reaction/54563
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate | HCID 1514258 | — |
| Reactant | 3-Ethoxycarbonyl-5-(4-cyanophenyl)-1,2,4-oxadiazole | HCID 19959148 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[{2-(1-Tert-butoxycarbonylpiperidin-4-yl)ethyl}carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole | HCID 19959295 | — |
Reaction Steps
A mixture of 3-ethoxycarbonyl-5-(4-cyanophenyl)-1,2,4-oxadiazole (2.0 g) and 2-(1-tert-butoxycarbonylpiperidin-4-yl)ethylamine in N,N-dimethylformamide (1 ml) was heated at 120° C. for 5 hours. The mixture was dissolved with ethyl acetate, washed with water, brine, dried over magnesium sulfate and evaporated in vacuo. The residue was recrystallized from ethanol to afford 3-[{2-(1-tert-butoxycarbonylpiperidin-4-yl)ethyl}carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole (2.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05622976 |
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| Source dataset | uspto-grants-1997_04 |
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| ORD ID | ord-1224fa790a994fbf9ceb4726555c59b7 |
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| Source note | uspto-grants-1997_04 |
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