Trifluoroacetic acid → HCID 67190361, compound

Participants

Reaction Steps

To a stirring mixture of 3-(4-methoxybenzyl)-1-benzyl-6-chloro-3,4-dihydroquinazolin-2(1H-one (0.2 g, 0.68 mmol) in DCM (5.0 mL) was added TFA (4.0 mL). The mixture was stirred at RT for 5 h. The reaction was monitored by MS, and upon completion, the reaction was concentrated. The crude residue was purified using flash column chromatography (100% DCM to 2% MeOH in DCM) to obtain the desired product 1-benzyl-6-chloro-3,4-dihydroquinazolin-2(1H)-one as a white solid. MS m/e 273 (M+H)+.

Provenance & Evidence