N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide → HCID 24967083, compound

HRID 545639Notes

Reaction equation

HRID 545639 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[C:7](=[O:18])[NH:6][CH2:5]2.[CH:19]1([NH:22][C:23](=[O:40])[C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[C:26](B3OC(C)(C)C(C)(C)O3)[CH:25]=2)[CH2:21][CH2:20]1>>[CH:19]1([NH:22][C:23](=[O:40])[C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[C:26]([C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[N:8]([CH:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:7](=[O:18])[NH:6][CH2:5]4)[CH:25]=2)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 21914577N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamideHCID 67188367HCID 67188367, compound

Product 1

HCID 24967083HCID 24967083, compound

Procedure

The title compound was prepared as pale yellow solid, using 6-Bromo-1-(tetrahydro-2H-pyran-4-yl)-3,4-dihydroquinazolin-2(1H)one and N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, by a method analogous to that described in Example 3 above. MS m/e 406 (M+H)+.

Sources & evidence

ORD record
ord-257fa6c7e41f41d68b3d746af7630025
Source dataset
uspto-grants-2011_05
Patent number
US07935709B2

Reaction notes

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