Hydrochloric Acid → 3-[{2-(Piperidin-4-yl)ethyl}carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole hydrochloride

Participants

Reaction Steps

To a solution of 3-[{2-(1-tert-butoxycarbonylpiperidin-4-yl)ethyl}carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole (2.5 g) in dioxane (30 ml) was added 4N hydrochloric acid in dioxane (13 ml) under ice cooling. After stirring for 5 hours at ambient temperature, the mixture was evaporated in vacuo. The residue was recrystallized from ethanol-ether to afford 3-[{2-(piperidin-4-yl)ethyl}carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole hydrochloride (1.71 g).

Provenance & Evidence