Phosphate → L-Leucine

HRID 545644Notes

Reaction equation

HRID 545644 reaction equation
N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC([NH:73][C@H:74]([C:79](N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCSC)=[O:80])[CH2:75][CH:76]([CH3:78])[CH3:77])=O)=O)CC1C=CC=CC=1)=O)CC1C=CC=CC=1)=O)CCC(=O)N)=O)CCC(=O)N)=O)=O)CCCCN)=O)=O)CCCNC(=N)N.P([O-])([O-])([O-])=[O:151]>>[NH2:73][C@H:74]([C:79]([OH:80])=[O:151])[CH2:75][CH:76]([CH3:77])[CH3:78]

Participants

3

Reactant 2

HCID 1061PhosphateHCID 131727003HCID 131727003, compound

Product 1

HCID 6106L-Leucine

Procedure

The degradation of H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-(Lys)6-NH2 (SEQ ID NO: 111) (˜4.7×10−5 M) in 50 mM phosphate buffer solutions of pH 7.4 containing carboxypeptidase A (1 U/ml) was studied as described above. The pseudo first-order rate constant for the degradation was estimated to 5.5×10−3 min−1 and the corresponding half-life calculated to 126 min as previously described.

Workup

  1. wait−1 and the corresponding half-life calculated to 126 min

Sources & evidence

ORD record
ord-3a3362ad0eef4cd290550f9059f433e9
Source dataset
uspto-grants-2011_05
Patent number
US07935786B2

Reaction notes

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