N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine → L-Leucine
Reaction equation
N[C@H](C(NCC(NCC(N[C@H](C([NH:32][C@H:33]([C:38]([OH:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36])=O)CC1C=CC=CC=1)=O)=O)=O)CC1C=CC(O)=CC=1>P([O-])([O-])([O-])=O>[NH2:32][C@H:33]([C:38]([OH:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The degradation H-Tyr-Gly-Gly-Phe-Leu-OH (SEQ ID NO: 12) (˜1.8×10−4 M) in 50 mM phosphate buffer solutions of pH 7.4 containing carboxypeptidase A (1 U/ml) was studied as described above. The pseudo first-order rate constant for the degradation was estimated to 9.8×10−1 min−1 and the corresponding half-life calculated to 0.7 min as previously described.
Workup
- wait−1 and the corresponding half-life calculated to 0.7 min
Sources & evidence
- ORD record
- ord-19dff3bc3a7c449d9a8970df8df95bcc
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07935786B2
Reaction notes
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