Hydrochloric Acid → 3-[[2-{1-(4-Fluorobenzyl)piperidin-4-yl}ethyl]carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole hydrochloride

Participants

Reaction Steps

A solution of 4N hydrogen chloride in ethyl acetate (0.56 ml) was added to a solution of 3-[[2-{1-(4-fluorobenzyl)piperidin-4-yl}ethyl]carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole (0.8 g) in ethyl acetate (20 ml) under ice cooling. The resulting precipitates were filtered off, washed with diethyl ether, and dried in vacuo to give 3-[[2-{1-(4-fluorobenzyl)piperidin-4-yl}ethyl]carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole hydrochloride (0.75 g).

Provenance & Evidence