Sodium Hydroxide → 3-[1-Hydroxy-4-(1-benzylpiperidin-4-yl)butyl]-5-(4-nitrophenyl)-1,2,4-oxadiazole

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-[1-acetoxy-4-(1-benzylpiperidin-4-yl)butyl]-5-(4-nitrophenyl)-1,2,4-oxadiazole (0.5 g) in methanol (10 ml) was added 4N an aqueous sodium hydroxide solution (0.5 ml) at 0° C. After stirring at 0° C. for 2 hours, ice water was added to the mixture and the precipitates were filtrated to give 3-[1-hydroxy-4-(1-benzylpiperidin-4-yl)butyl]-5-(4-nitrophenyl)-1,2,4-oxadiazole (0.44 g). The compound (100 mg) was dissolved in a solution of fumaric acid (27 mg) in ethanol to give 3-[1-hydroxy-4-(1-benzylpiperidin-4-yl)butyl]-5-(4-nitrophenyl)-1,2,4-oxadiazole fumarate (0.1 g).

Provenance & Evidence