反应详情

To a solution of 5-[4-(amino)butylthio]imidazo[1,2-a]pyridine (300 mg, 1.36 mmoles) and triethylamine (0.29 ml, 2.08 mmoles) in methylene chloride (15 ml) was added 1-naphthalenesulfonyl chloride (307 mg, 1.35 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for 1 hour. The reaction mixture was washed in turn with an aqueous sodium bicarbonate solution and water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography (eluent: ethyl acetate) to obtain 296 mg of the desired product (53.0%, colorless solid).

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 1 hour
3. washThe reaction mixture was washed in turn with an aqueous sodium bicarbonate solution and water
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationAfter the solvent was distilled off
6. customthe residue was purified by column chromatography (eluent: ethyl acetate)