HCID 58872447, compound → HCID 58872440, compound

HRID 545802Notes

Reaction equation

HRID 545802 reaction equation
BrC1C=CC=C2C=1C(C1C(O)=CC3OCOC=3C=1)[C:5](=[O:16])N2CCCCC.[OH:27][C:28]1[C:36]([CH:37]2[C:45]3[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=3)[N:39]([CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])[C:38]2=[O:51])=[CH:35][C:31]2[CH2:32][CH2:33][O:34][C:30]=2[CH:29]=1>>[OH:27][C:28]1[C:36]([C:37]2([CH2:5][OH:16])[C:45]3[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=3)[N:39]([CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])[C:38]2=[O:51])=[CH:35][C:31]2[CH2:32][CH2:33][O:34][C:30]=2[CH:29]=1

Participants

3

Reactant 2

HCID 58872447HCID 58872447, compoundHCID 588725004-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 58872440HCID 58872440, compound

Procedure

Following the procedure as described in PREPARATION 1E, and making non-critical variations to replace 4-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one with 3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one, the title compound was obtained (46%): MS (ES+) m/z 368.3 (M+1), 380.4 (M+23).

Sources & evidence

ORD record
ord-ddea435bae1446a68417e287c529a1e7
Source dataset
uspto-grants-2011_05
Patent number
US07935721B2

Reaction notes

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