Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Trifluoromethoxy)benzyl bromide → 1'-[2-(trifluoromethoxy)benzyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Trifluoromethoxy)benzyl bromide | HCID 2777254 | — |
| 반응물 | 2-(Bromomethyl)-5-(trifluoromethyl)furan | HCID 2794605 | — |
| 반응물 | spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one | HCID 53375495 | — |
| 반응물 | 5,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1H)-one | HCID 59263470 | — |
| 생성물 | 1'-[2-(trifluoromethoxy)benzyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one | HCID 59263398 | — |
반응 단계
Following the procedure described in EXAMPLE 10.21, and making non-critical variations using spiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-2′(1′H)-one to replace 5,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b′]difuran-3,3′-indol]-2′(1′H)-one, and 1-(bromomethyl)-2-(trifluoromethoxy)benzene to replace 2-(bromomethyl)-5-(trifluoromethyl)furan, the title compound was obtained (77%) as a white solid: mp 130-135° C.; MS (ES+) m/z 456.3 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07935721B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-edcbf3a56d2a453b8e100f6b9a02d723 |
| 출처 메모 | uspto-grants-2011_05 |