1'-(diphenylmethyl)-5-pyridin-3-ylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one → 5-piperidin-3-ylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 545970Notes

Reaction equation

HRID 545970 reaction equation
C1(C(C2C=CC=CC=2)[N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]3([C:20]4[CH:21]=[C:22]([C:25]5[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=5)[CH:23]=[CH:24][C:19]=4[O:18][CH2:17]3)[C:9]2=[O:31])C=CC=CC=1.C1(C(C2C=CC=CC=2)N2C3C(=CC(C)=CC=3)C3(C4=CC5OCOC=5C=C4OC3)C2=O)C=CC=CC=1>>[NH:27]1[CH2:28][CH2:29][CH2:30][CH:25]([C:22]2[CH:23]=[CH:24][C:19]3[O:18][CH2:17][C:10]4([C:11]5[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=5)[NH:8][C:9]4=[O:31])[C:20]=3[CH:21]=2)[CH2:26]1

Participants

3

Reactant 2

HCID 592634281'-(diphenylmethyl)-5-pyridin-3-ylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-oneHCID 59263474(diphenylmethyl)-5'-methylspiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Product 1

HCID 666427235-piperidin-3-ylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Procedure

Following the procedure as described in EXAMPLE 1.28, and making non-critical variations using 1′-(diphenylmethyl)-5-pyridin-3-ylspiro[1-benzofuran-3,3′-indol]-2′(1′H)-one to replace 1′-(diphenylmethyl)-5′-methylspiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-2′(1′H)-one, the title compound was obtained that was used in the next step.

Sources & evidence

ORD record
ord-9386dbbdfdea401387db843c40fda46d
Source dataset
uspto-grants-2011_05
Patent number
US07935721B2

Reaction notes

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