(3-Nitro-pyrazol-1-yl)-propionic acid tert-butyl ester → (3-Amino-pyrazol-1-yl)-propionic acid tert-butyl ester

Participants

Reaction Conditions

Reaction Steps

To a solution containing (3-nitro-pyrazol-1-yl)-propionic acid tert-butyl ester (2.30 g, 9.53 mmol) in methanol (100 mL), palladium, 10 wt. % on activated carbon, wet (˜300 mg) was added to the solution. The vial was charged with hydrogen gas (via balloon) and the mixture was stirred for 16 h at 25° C. The mixture was passed through a plug of celite and concentrated in vacuo to afford (3-amino-pyrazol-1-yl)-propionic acid tert-butyl ester (1.87 g, 93%) as a yellow oil which was used in the following step with no further purification.

Provenance & Evidence